Germfree and Gnotobiotic Animal Models: Background and Applications

摘要: Introduction Early Growth, Body Weight, Reproduction, and Life Span General Aspects Growth Weight of the Mature Animal Reproduction Conclusions Anatomy, Morphology, Function Gastrointestinal System Stomach Small Intestine Cecum Large Morphology Physiology, Endocrinology Biochemistry Energy Metabolism Liver Cholesterol Bile Acid Rats Mice Gerbils Dogs Pigs Other Indicators Water Balance Kidney Mineral Endocrine Nutrition Rat Mouse Diets Hand-Feeding Cesarean-Derived Newborn Solid Further Development Sterilization Metabolic Requirements Germfree Mice-Contributions Microflora Dietary Proteins Amino Acids Vitamin B Complex-Microflora Production Fat-Soluble Vitamins Minerals Inositol, Ubiquinone, Queuine The Chemically Defined Diet Procedures Present Status Antigenicity Immune Potential Immunology, Including Radiobiology Transplantation Studies: Maintained on Antibody-Forming Phagocytosis Cells, T NK Cells Globulins Natural Antibody Cytokinins Radiation Biology Bone Marrow Immunological Evaluation GF a Defined, Low Molecular Antigen-Free Parasitology Effects Via Nutrient Availability Protozoa Nematodes Helminths Schistosomiasis Chagas' Disease Cestodes Pathology Over Tumors Tumor-Related Viruses Applications: Past, Present, Future. Part I Microbial Action Interaction in Gnotobiotic Systems: Colonization Resistance Translocation Studies Controlled Association Materials with Antimicrobial II. Use Gnotobiote Study Aging Syndrome "Endpoint Studies" Lobund Cancer Research Role Steroid Cardiovascular Dental Caries Periodontal Biology: Effect Bacterial Lipopolysaccharides (LPS) Shock Syndrome: Influence LPS Hemorrhagic Thermal Intestinal Strangulation Tourniquet Ulcerative Colitis Swine III. Monoclonal Antibodies Future Considerations Index