Cardiopulmonary pathology in patients with sleep apnea/obesity hypoventilation syndrome.

摘要: We reviewed clinical data, autopsy reports, and microscopic slides on 10 patients with sleep apnea/obesity hypoventilation syndrome (SA/OHS) to define the cardiopulmonary pathological features establish clinicopathologic correlations. Ten obese (>136 kg) without SA/OHS were studied as controls. Patients exhibited biventricular cardiac failure pulmonary hypertension a higher prevalence of moderate/severe hemosiderosis (8 v 0 patients), alveolar hemorrhage (7 4 capillary proliferation (4 iron encrustation elastica (1 patients) medial hypertrophy muscular arteries (11.9 +/- 2.4 9.7 1.6%) (P < .05). In two resembled hemangiomatosis. Mean right ventricular thickness was in group (0.71 0.17 0.42 0.1 cm) .01). Four three controls had myocardial fibrosis. Biventricular caused death seven SA/OHS. Hypoxia is probably most important cause hypertension, arterial muscularization, SA/ OHS. Left some may be result hypertensive disease. others, etiology left not determined morphologically, suggesting functional abnormalities related obesity and/or apneic episodes.