Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell's Viper Bites with Coagulopathy
作者： Geoffrey K. Isbister , Kalana Maduwage , Fiona E. Scorgie , Seyed Shahmy , Fahim Mohamed
DOI: 10.1371/JOURNAL.PNTD.0003968
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摘要: BACKGROUND: Russell's viper envenoming is a major problem in South Asia and causes venom induced consumption coagulopathy. This study aimed to investigate the kinetics dynamics of clotting function envenoming. METHODOLOGY/PRINCIPAL FINDINGS: In prospective cohort 146 patients with envenoming, we measured concentrations, international normalised ratio [INR], prothrombin time (PT), activated partial thromboplastin (aPTT), coagulation factors I, II, V, VII, VIII, IX X, von Willebrand factor antigen. The median age was 39y (16-82y) 111 were male. peak INR 6.8 (interquartile range[IQR]:3.7 >13), associated low fibrinogen [median,3 at 6h post-antivenom but had reduced CONCLUSIONS: coagulopathy results prolonged aPTT, INR, fibrinogen, VIII X which recover over 48h. Severity abnormalities concentrations. Language: en
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