Impact of ATP-binding cassette transporters on human immunodeficiency virus therapy.
作者： Johanna Weiss , Walter Emil Haefeli
DOI: 10.1016/S1937-6448(10)80005-X
关键词:
摘要: Even though potent antiretrovirals are available against human immunodeficiency virus (HIV)-1 infection, therapy fails in a significant fraction of patients. Among the most relevant reasons for treatment failure drug toxicity and side effects, but also development viral resistance towards drugs applied. Efflux by ATP-binding cassette (ABC-) transporters represents one major mechanism influencing pharmacokinetics antiretroviral particularly their distribution, thus modifiying concentration within infected cells, that is, at site action. Moreover, drug-drug interactions may occur level these modulate activity or expression efficacy substrate drugs. This review summarizes current knowledge on interaction used HIV-1 with ABC-transporters highlights impact cellular therapeutic success. suitability different cell models studying is discussed.
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