Interaction Potential of Etravirine with Drug Transporters Assessed In Vitro
作者： Nadine Cécile Luise Zembruski , Walter Emil Haefeli , Johanna Weiss
DOI: 10.1128/AAC.01527-10
关键词:
摘要: Etravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infections. ABC transporters potentially mediate clinically relevant drug-drug interactions. We assessed substrate characteristics and inhibitory inductive potential etravirine on transporters. did not inhibit P-gp/ABCB1 was transported by tested but potent BCRP/ABCG2. induced several transporters, especially These data demonstrate that has interactions modulation expression function
sci-hub.se 参考文章(26)
Johanna Weiss, Walter Emil Haefeli, Impact of ATP-binding cassette transporters on human immunodeficiency virus therapy. International Review of Cell and Molecular Biology. ,vol. 280, pp. 219- 279 ,(2010) , 10.1016/S1937-6448(10)80005-X
Laura Dickinson, Saye Khoo, David Back, Pharmacokinetics and drug-drug interactions of antiretrovirals: an update. Antiviral Research. ,vol. 85, pp. 176- 189 ,(2010) , 10.1016/J.ANTIVIRAL.2009.07.017
Kevin C. Brown, Sunita Paul, Angela D.M. Kashuba, Drug interactions with new and investigational antiretrovirals. Clinical Pharmacokinectics. ,vol. 48, pp. 211- 241 ,(2009) , 10.2165/00003088-200948040-00001
Yaming Su, Xiaoping Zhang, Patrick J. Sinko, Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Molecular Pharmaceutics. ,vol. 1, pp. 49- 56 ,(2004) , 10.1021/MP0340136
Monika Schöller-Gyüre, Wim van den Brink, Thomas N. Kakuda, Brian Woodfall, Goedel D. Smedt, Hilde Vanaken, Tanja Stevens, Monika Peeters, Kati Vandermeulen, Richard M. W. Hoetelmans, Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers. The Journal of Clinical Pharmacology. ,vol. 48, pp. 322- 329 ,(2008) , 10.1177/0091270007310387
Petr Pavek, Gracia Merino, Els Wagenaar, Ellen Bolscher, Martina Novotna, Johan W. Jonker, Alfred H. Schinkel, Human breast cancer resistance protein : Interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine Journal of Pharmacology and Experimental Therapeutics. ,vol. 312, pp. 144- 152 ,(2005) , 10.1124/JPET.104.073916
Maarten T Huisman, Johan W Smit, Kristel ML Crommentuyn, Noam Zelcer, Hugh R Wiltshire, Jos H Beijnen, Alfred H Schinkel, Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. ,vol. 16, pp. 2295- 2301 ,(2002) , 10.1097/00002030-200211220-00009
Thomas N Kakuda, Monika Schöller-Gyüre, Richard MW Hoetelmans, Clinical perspective on antiretroviral drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor etravirine. Antiviral Therapy. ,vol. 15, pp. 817- 829 ,(2010) , 10.3851/IMP1652
J. Weiss, A. Sauer, N. Divac, M. Herzog, E. Schwedhelm, R. H. Böger, W. E. Haefeli, R. A. Benndorf, Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharmaceutics & Drug Disposition. ,vol. 31, pp. 150- 161 ,(2010) , 10.1002/BDD.699
L. Zhang, Y. (D.) Zhang, J. M. Strong, K. S. Reynolds, S.-M. Huang, A regulatory viewpoint on transporter-based drug interactions. Xenobiotica. ,vol. 38, pp. 709- 724 ,(2008) , 10.1080/00498250802017715