G×E Interaction Influences Trajectories of Hand Grip Strength

摘要: Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While is heritable, genetic influence on change has been relatively ignored, with non-shared environmental identified as the pri- mary contributor a single longitudinal study. The extent to which gene-environment interplay, particularly gene- environment interactions, contributes trajectories yet be examined. We considered measurements seven twin studies of aging Interplay Genes Environment across Multiple Studies consortium. Growth curve parameters were esti- mated for same-sex pairs, aged 34-99 (N = 10,681). Fisher's test mixture distribution within-monozy- gotic twin-pair differences 1724) was performed growth parameters. observed significant interaction trajectories. Finally, we compared variability within-pair differ- ences by APOE haplotypes. Though not statistically significant, results suggested that e2e2/e2e3 haplotypes might buffer environ- mental influences