Ten years in: APOL1 reaches beyond the kidney.
作者： Joshua S. Waitzman , Jennie Lin
DOI: 10.1097/MNH.0000000000000511
关键词:
摘要: Purpose of review APOL1 nephropathy risk variants drive most the excess chronic kidney disease (CKD) seen in African Americans, but whether same account for cardiovascular remains unclear. This mini-review highlights controversies field. Recent findings In past 10 years, our understanding how contribute to renal cytotoxicity has increased. Some proposed mechanisms are biologically plausible cells and tissues relevant (CVD), studies published since 2014 have reported conflicting results regarding variant association with outcomes. year, several also contributed from different types study populations. Summary Heterogeneity population design led differing reports on role CVD. Without consistently validated associations between these CVD, mechanistic APOL1's biology lag behind.
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