Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats.

摘要: A total of 33 extracts from 18 Cameroonians plants were studied in two vitro test systems to determine potential estrogenic activities. The activities the extracts, which have shown promising activity on both screens further investigated vivo ovariectomized Wistar rats. All screened yeast test-system. Five these namely ethyl acetate extract stem bark Millettia conraui, drastica, methanol leaves Bridelia ferruginea, roots Pseudarthria hookeri and Nauclea latifolia showed interesting properties, therefore alkaline Phosphase induction Ishikawa cells. hoockeri significant stimulatory effects at 10 100 mg/ml doses. ferruginea was not evaluated because its toxicity This effect completely inhibited by a combined treatment with pure antiestrogen ICI (Faslodex, 5 x 10(-7) M). In experiments that per os administration 200 mg/kg bw conraui significantly increased uterine epithelial height 17.93% 28.08% respectively compared uteri controls after 7 days treatment. Uterine animals treated rg/kg bw/d ethinylestradiol 242.3% same experiment. Extracts drastica had no ovariectomised latifolia, given orally vaginal 15.64%, 24.06%, 51.02% 58.12% following regiment untreated controls. line data finding cornification presence each more advanced than although as prominent response These results suggest some constituents hookeri, may activity.