Bmi‑1 induces radioresistance by suppressing senescence in human U87 glioma cells

摘要: Radiotherapy is the main locoregional control modality for a number of types malignant tumors, including glioblastoma. However, radiotherapy fails to prevent recurrence in numerous patients due intrinsic radioresistance cancer cells. Cell senescence significant tumor suppressor mechanisms and closely associated with Bmi-1 has been proposed be an oncogene that can induce anti-senescence The present study investigated response U87 glioma cells radiation exposure role following radiotherapy. apoptosis cell cycle distribution were assessed using flow cytometry, SA-β-Gal stain was used observe ratio radiation. expression exposed different doses evaluated by western blot analysis. X-ray found inhibit proliferation through induction rather than apoptosis. Following radiation, dysregulated, increased G2/M phase, upregulated, particularly when dose ≥6 Gy administered. results indicated mechanism which growth inhibited In addition, may increasing enabling senescence.