Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System

摘要: Abstract Alkaloids constitute a huge group of natural products, and some them have been extensively studied for their activity on targets related to the central nervous system (CNS), especially neurodegenerative diseases depression. In this context, inhibition monoamine oxidases (MAOs) was considered in search products with promising scaffolds drug development. Among various classes, indole alkaloids possess biological pharmacological properties CNS, mainly serotonergic glutamatergic transmission. Those containing β-carboline moiety, such as harmane, are known MAOs. Another class number studies MAOs is that isoquinoline alkaloids. Chelidonine, representative group, shows specific irreversible MAO-A. The conducted so far selectivity between MAO-A -B inhibitors contributed better understanding structure–activity relationship (SAR) classes One example desoxypeganine, quinazoline alkaloid presents selective Due its inhibition, naturally occurring has clinically investigated potential application an alcohol smoking cessation aid. On other hand, quinolone presented vitro MAO-B age-related diseases. Several examples given chapter consider MAO isoforms SAR issues