Association of cigarette smoking and tar and nicotine intake with development of type 2 diabetes mellitus in men and women from the general population: the MONICA/KORA Augsburg Cohort Study

摘要: We examined sex-specific associations between cigarette smoking and incident type 2 diabetes mellitus in Germany. The study was based on 5,470 men 5,422 women (aged 25–74 years) without who participated one of the three population-based MONICA Augsburg surveys 1984 1995. Incident cases were assessed using follow-up questionnaires. Hazard ratios (HRs) estimated from Cox proportional hazard models. Up to 31 December 2002 a total 409 among 263 registered. number cigarettes nicotine tar consumption per day associated with significantly increased risk men, but not women; this could be due low power women. After multivariable adjustment, HRs for compared never-smokers 1.48, 2.03 2.10 1 14, 15 19 ≥20 cigarettes/day (p trend <0.0001) 1.25, 1.34 1.37 9, 10 0.0985). Compared never-smokers, increasing intake (1–167, 168–259 ≥260 mg/day) 1.45, 2.32 2.07 <0.0001); respective (1–89, 90–194 ≥195 mg/day) 1.18, 1.57 1.24 0.1159). Cigarette is an important modifiable factor particularly general population.