Treatment of patients with Paget's disease of bone.

摘要: Paget's disease is a progressive bone disease, monostotic or polyostotic, characterised by hypertrophy of affected bones and accelerated disorganised remodelling. It results in deformities pain, with risk for articular neurological complications, fractures. The thus the therapeutic decision, function age patient, severity activity disease. Bisphosphonates are first-line therapy advent new bisphosphonates permits dramatic improvement treatment. optimal treatment regimen should obtain normalisation quasi-normalisation markers This result has potential long-term control