Design, Synthesis, and SAR Studies of 4-Substituted Methoxylbenzoyl-aryl-thiazoles Analogues as Potent and Orally Bioavailable Anticancer Agents
作者： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Michael L. Mohler
DOI: 10.1021/JM2003427
关键词:
摘要: … Compound 20 was designed to mimic the structure of CA-4, which contain a cis-C═C between two aryl rings, unfortunately 20(Z) and other isomer 21(E) lost activity after replacing the C…
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