Palladium-Catalyzed N-Arylation of 2-Aminothiazoles
作者： Meredeth A. McGowan , Jaclyn L. Henderson , Stephen L. Buchwald
DOI: 10.1021/OL300178J
关键词:
摘要: A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, this class nucleophiles, exhibits a broad substrate scope proceeds reasonable catalyst loading. Furthermore, an interesting effect acetic acid as additive uncovered that facilitates activation.
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