In vivo and in vitro methods for evaluating soil arsenic bioavailability: relevant to human health risk assessment.
作者： Karen D Bradham , Gary L Diamond , Michele Burgess , Albert Juhasz , Julie M Klotzbach
DOI: 10.1080/10937404.2018.1440902
关键词:
摘要: ABSTRACTArsenic (As) is the most frequently occurring contaminant on priority list of hazardous substances, which lists substances greatest public health concern to people living at or near U.S. National Priorities List site. Accurate assessment human risks from exposure As-contaminated soils depends estimating its bioavailability, defined as fraction ingested As absorbed across gastrointestinal barrier and available for systemic distribution metabolism. Arsenic bioavailability varies among influenced by site-specific soil physical chemical characteristics internal biological factors. This review describes state-of-the science that supports our understanding oral As, methods are currently being explored relative (RBA), future research areas could improve prediction RBA in humans. The following topics addressed: (1) geochem...
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