In vitro bioaccessibility and in vivo relative bioavailability in 12 contaminated soils: Method comparison and method development
作者： Jie Li , Kan Li , Xin-Yi Cui , N.T. Basta , Li-Ping Li
DOI: 10.1016/J.SCITOTENV.2015.05.113
关键词:
摘要: Previous studies have established in vivo-in vitro correlations (IVIVC) between arsenic (As) relative bioavailability (RBA) and bioaccessibility contaminated soils. However, their ability to predict As-RBA soils outside the models is unclear. In this study, As 12 As-contaminated (22.2-4172 mg kg(-1) As) were measured using five assays (SBRC, IVG, DIN, PBET, UBM) a mouse blood model. Arsenic RBA ranged from 6.38 ± 2.80% 73.1 17.7% with containing higher extractable Fe showing lower values. varied within assays. was used as input values into IVIVC There significant differences predicted for soils, illustrating inability of those Therefore, new by correlating The strength predictive r(2) = 0.50 PBET 0.83 IVG assay providing best prediction As-RBA. When compared Juhasz et al. (2014a), slopes relationships significantly possibly due different measurements. Our research showed that has potential measure China though UBM SBRC also suitable. More needed verify suitability refining health risk assessment.
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