In Vivo Validation of the Unified BARGE Method to Assess the Bioaccessibility of Arsenic, Antimony, Cadmium, and Lead in Soils

作者: Sébastien Denys , Julien Caboche , Karine Tack , Guido Rychen , Joanna Wragg

DOI: 10.1021/ES3006942

关键词:

摘要: The relative bioavailability of arsenic, antimony, cadmium, and lead for the ingestion pathway was measured in 16 soils contaminated by either smelting or mining activities using a juvenile swine model. contained 18 to 25,000 mg kg(-1) As, 60,000 Sb, 20 184 Cd, 1460 40,214 Pb. kidney, liver, bone, urine soluble salts four elements. variety soil types, total concentrations elements, range bioavailabilities found were considered be suitable calibrating vitro Unified BARGE bioaccessibility method. test has been developed BioAccessibility Research Group Europe (BARGE) is known as Method (UBM). study looked at end points from vivo measurements two compartments ("stomach" "stomach intestine"). Using benchmark criteria assessing "fitness purpose" UBM data act an analogue risk assessment, shows that met on repeatability (median standard deviation value 0.6) suggest small bias As Pb compared 3% 5% respectively. Sb did not meet due values samples.

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