N-Methyl-(R)salsolinol as a dopaminergic neurotoxin: From an animal model to an early marker of Parkinson’s disease
作者： M. Naoi , W. Maruyama , P. Dostert , Y. Hashizume
DOI: 10.1007/978-3-7091-6842-4_10
关键词:
摘要: A dopamine-derived 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydrosioquinoline [N-methyl-(R)salsolinol] was found to occur enantio-selectively in human brain. This isoquinoline induced parkinsonism rat after injection the striatum, and behavioral, biochemical pathological changes were very similar those Parkinson’s disease. N-Methyl-(R)salsolinol depleted dopamine neurons substantia nigra without necrotic tissue reaction, which may be due apoptotic death process, as proved by its induction of DNA damage dopaminergic neuroblastoma SH-SY5Y cells. increase significantly cerebrospinal fluid parkinsonian patients. All these results suggest that N-methyl-(R)salsolinol an endogenous neurotoxin cause disease enzymes involved biosynthesis catabolism factors pathogenesis this
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