d-Glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K
作者： Hyun-Ji Oh , Jason S. Lee , Dae-Kyu Song , Dong-Hoon Shin , Byeong-Churl Jang
DOI: 10.1016/J.BBRC.2007.06.137
关键词:
摘要: Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and vitro, the mechanism for anticancer effect is still unclear. Since there are several reports suggesting inhibits protein synthesis, we examined whether affects p70S6K activity, important signaling molecule involved translation. In present study, found inhibited activity proliferation DU145 prostate cancer cells MDA-MB-231 breast cells. decreased phosphorylation p70S6K, its downstream substrates RPS6, eIF-4B, but not mTOR 4EBP1 cells, that induced inhibition through mTOR. addition, enhanced inhibitory effects rapamycin, a specific These findings suggest can inhibit dephosphorylation p70S6K.
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