A molecular modelling study of the interaction of noradrenaline with the β 2 -adrenergic receptor.
作者： T. J. Mitchell , M. S. Tute , G. A. Webb
DOI: 10.1007/BF01533069
关键词:
摘要: A model of theβ2-adrenergic receptor binding site is built from the primary structure receptor, experimental evidence for key residues and analogy with a homologous protein partially determined structure. It suggested that Trp-109, Thr-110 Asp-113 are involved in ligand binding. Noradrenaline successfully docked into this model, results an INDO molecular orbital calculation on complex indicate charge transfer interaction between Trp-109 noradrenaline possible.
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