Post-traumatic survival and recovery of the auditory sensory cells in culture.

摘要: Following mechanical injury in organotypic cultures, auditory hair cells show the ability to survive and initially reform their apical specializations, cuticular plates stereocilia, but none incorporation of tritiated thymidine, mitotic marker. Disruption reticular lamina local cell induces proliferation supporting cells. The regenerating apices inner are wrapped by spiral sulcus phalangeal cells, while those outer processes Deiters' Some these subsequently resurface with newly formed tops. Hair that lose contact surface organ remain buried--but alive--deep within epithelium. Our study provides evidence mammalian Corti responds not formation new sensory recovery pre-existing postmitotic