Therapeutic evaluation of oxantel pamoate (1, 4, 5, 6-tetrahydro-1-methyl-2-[trans-3-hydroxystyryl] pyrimidine pamoate) in severe Trichuris trichiura infection.

摘要: Abstract The efficacy of oxantel pamoate (1,4,5,6-tetrahydro-2-[trans-3-hydroxystyryl]-1-methyl pyrimidine pamoate) was evaluated in 25 children with severe Trichuris infection. The presence chronic dysentery and sigmoidoscopic demonstration whipworms the intestinal mucosa were criteria for inclusion trial. Most these patients had anemia, rectal prolapse, digital clubbing, hypoproteinemia, growth retardation. There a high incidence concomitant parasitism other helminths Entamoeba histolytica Giardia lamblia. Sigmoidoscopic grading load egg count feces carried out prior to treatment 2 days after each course therapy. Oxantel administered at dose 10 mg/kg body weight twice daily 3-day course. Satisfactory response, as judged by relief absence from sigmoidoscopy, achieved 17 first remaining 8 second oxantel. drug well tolerated no side effects noted during or treatment. It is concluded that safe effective anthelmintic clinical trichuriasis.