Increasing Incidence of Pediatric Type 1 Diabetes Mellitus in Southeastern Wisconsin: Relationship with Body Weight at Diagnosis

摘要: Introduction Several studies have confirmed the increasing rate of type 1 diabetes mellitus (T1DM) in children and link with BMI at diagnosis termed ‘accelerator hypothesis’. Our objective was to assess whether changing incidence a group adolescent from Midwest United States associated changes BMI. Methods Data 1618 (52.1% M/47.9% F) newly-diagnosed adolescents (<19 years) T1DM, admitted Children's Hospital Wisconsin (CHW) between January 1995 December 2004, analyzed relationship body mass index (BMI) standard deviation score (SDS). Results An overall, 10-year cumulative 27.92 per 100,000 (19.12 41.72/100,000) observed, an average yearly 2.39%. The increase largest younger age groups, 0–4, 5–9, 10–14 having 2.4, 2.3, 3.0%, respectively, corresponding relative 25.3, 33.8, 38.0%, respectively. Age inversely correlated SDS (p<0.001) remained significant for both males females. Conclusions Annual T1DM increased two-fold CHW over study period. majority observed youngest which also appeared be heaviest. This research adds growing literature supporting hypothesis that excess weight gain during childhood may risk factor early manifestation T1DM.