Genomic and proteomic determinants of lower extremity revascularization failure: rationale and study design.

摘要: This translational research program applies a working model of advanced functional genomics/proteomics and bioinformatics to human peripheral arterial occlusive disease (PAOD). It is multidisciplinary collaborative effort clinicians, scientists, statisticians with an advisory panel consisting experts in inflammation biology, vascular molecular genetics, bioinformatics, clinical trial design, epidemiology. The proposed initiative designed study 300 symptomatic patients PAOD undergoing medical management or without intervention by lower extremity angioplasty/stenting vein graft bypass. aims test the hypothesis that systemic inflammatory response after influences local milieu responsible for repair adaptation. expectation this not uniform all but, rather, modulated either preoperative genetic predisposition postprocedure differential regulation innate immune injury promotes maladaptive phenotype leading failure. Therefore, some these differences may be present detectable before amenable class prediction prospective treatment strategies, whereas others early postprocedural period, onset failure, permitting interventions prevent adverse outcome. combination genomic/proteomic data together quality-of-life outcome measures define critical analysis should lead new knowledge about failure mechanisms strategies improve existing approaches revascularization.