Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation.
作者： Praveen C. Ashok , Anna Chiara De Luca , Michael Mazilu , Kishan Dholakia
关键词:
摘要: Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based detection system in microfluidic platform enabling the spectroscopic of analyte. It offers possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by auto-fluorescence background. Here we report enhanced combining WCRS continuous wavelength modulation technique. We used urea as model analyte and parameters have been optimized maximize device. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
elsevier.com
researchgate.net 
core.ac.uk 
sci-hub.se 参考文章(22)
Andrew P. Shreve, Nerine J. Cherepy, Richard A. Mathies, Effective Rejection of Fluorescence Interference in Raman Spectroscopy Using a Shifted Excitation Difference Technique Applied Spectroscopy. ,vol. 46, pp. 707- 711 ,(1992) , 10.1366/0003702924125122
Pertti J. Viskari, James P. Landers, Unconventional detection methods for microfluidic devices Electrophoresis. ,vol. 27, pp. 1797- 1810 ,(2006) , 10.1002/ELPS.200500565
Michael Mazilu, Anna Chiara De Luca, Andrew Riches, C. Simon Herrington, Kishan Dholakia, Optimal algorithm for fluorescence suppression of modulated Raman spectroscopy. Optics Express. ,vol. 18, pp. 11382- 11395 ,(2010) , 10.1364/OE.18.011382
Anna Chiara De Luca, Michael Mazilu, Andrew Riches, C. Simon Herrington, Kishan Dholakia, Online Fluorescence Suppression in Modulated Raman Spectroscopy Analytical Chemistry. ,vol. 82, pp. 738- 745 ,(2010) , 10.1021/AC9026737
Praveen C. Ashok, Gajendra P. Singh, Helen A. Rendall, Thomas F. Krauss, Kishan Dholakia, Waveguide confined Raman spectroscopy for microfluidic interrogation. Lab on a Chip. ,vol. 11, pp. 1262- 1270 ,(2011) , 10.1039/C0LC00462F
Scott T. McCain, Rebecca M. Willett, David J. Brady, Multi-excitation Raman spectroscopy technique for fluorescence rejection Optics Express. ,vol. 16, pp. 10975- 10991 ,(2008) , 10.1364/OE.16.010975
M. L. Myrick, S. M. Angel, Elimination of Background in Fiber-Optic Raman Measurements Applied Spectroscopy. ,vol. 44, pp. 565- 570 ,(1990) , 10.1366/0003702904087235
Nicholas D. Magee, Julien S. Villaumie, Eric T. Marple, Madeleine Ennis, J. Stuart Elborn, John J. McGarvey, Ex vivo diagnosis of lung cancer using a Raman miniprobe. Journal of Physical Chemistry B. ,vol. 113, pp. 8137- 8141 ,(2009) , 10.1021/JP900379W
P. C. Ashok, R. F. Marchington, P. Mthunzi, T. F. Krauss, K. Dholakia, Optical chromatography using a photonic crystal fiber with on-chip fluorescence excitation Optics Express. ,vol. 18, pp. 6396- 6407 ,(2010) , 10.1364/OE.18.006396
Taehan Park, Sangyeop Lee, Gi Hun Seong, Jaebum Choo, Eun Kyu Lee, Yang S. Kim, Won Ho Ji, Seung Yong Hwang, Dae-Gab Gweon, Sanghoon Lee, Highly sensitive signal detection of duplex dye-labelled DNA oligonucleotides in a PDMS microfluidic chip: confocal surface-enhanced Raman spectroscopic study Lab on a Chip. ,vol. 5, pp. 437- 442 ,(2005) , 10.1039/B414457K