Chapter 1 HLA‐Mediated Control of HIV and HIV Adaptation to HLA

摘要: The human immunodeficiency virus (HIV) epidemic provides a rare opportunity to examine in detail the initial stages of host-pathogen co-evolutionary struggle humans. genes encoding leukocyte antigen (HLA) class I molecules have critical influence success or failure immune response against HIV. particular HLA expressed by each individual defines type cytotoxic T-lymphocyte (CTL) that is made virus. This chapter describes role and CTL controlling HIV replication, discusses extent which has already adapted those responses are most effective viral suppression. It evident mutations enable evade indeed accumulating populations where selecting highly prevalent, indicating dynamic shifting nature evolutionary interplay between populations.