Cumulative Impact of Host and Viral Factors on HIV-1 Viral-Load Control during Early Infection

作者: L. Yue , H. A. Prentice , P. Farmer , W. Song , D. He

DOI: 10.1128/JVI.02118-12

关键词: PhenotypeAlleleTransmission (medicine)VirologyVirusHuman leukocyte antigenImmunologyHost (biology)BiologyHuman immunodeficiency virus (HIV)Viral load

摘要: In HIV-1 infection, the early set-point viral load strongly predicts both transmission and disease progression. The factors responsible for wide spectrum of loads are complex likely reflect an interplay between transmitted virus genetically defined in transmitting source partner seroconverter. Indeed, analysis 195 pairs from Lusaka, Zambia, revealed that partners contributed only ∼2% variance seroconverters (P = 0.046 by univariable analysis). multivariable models, seroconverting were a function (i) partner, (ii) gender seroconverter, (iii) specific HLA class I alleles newly infected (iv) sharing HLA-I pair. Each these significantly independently to accounting up 37% observed suggesting many operate concert define virological phenotype infection.

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