摘要: The design and effectiveness of strategies to promote long-term graft acceptance requires a fundamental understanding the mechanisms underlying acute chronic rejection. This chapter discusses two pathways allorecognition--direct indirect--and suggests that direct pathway plays major role in early weeks after transplantation indirect may contribute process results vitro vivo experimental models are discussed, together with clinical data.
springer.com
humanapress.com参考文章(43)
S. F. Grammer, Ruoping Dai, J. W. Streilein, Fresh and cultured Langerhans cells display differential capacities to activate hapten-specific T cells. Journal of Immunology. ,vol. 150, pp. 59- 66 ,(1993)
Michael J. Bevan, High determinant density may explain the phenomenon of alloreactivity Immunology Today. ,vol. 5, pp. 128- 130 ,(1984) , 10.1016/0167-5699(84)90233-0
Fritz H. Bach, Marilyn L. Bach, Paul M. Sondel, Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature. ,vol. 259, pp. 273- 281 ,(1976) , 10.1038/259273A0
J. Wayne Streilein, Susan R Grammer, Takeshi Yoshikawa, Aicha Demidem, Martin Vermeer, Functional dichotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes. Immunological Reviews. ,vol. 117, pp. 159- 183 ,(1990) , 10.1111/J.1600-065X.1990.TB00572.X
Biagio A. Pietra, Alex Wiseman, Amy Bolwerk, Mona Rizeq, Ronald G. Gill, CD4 T cell–mediated cardiac allograft rejection requires donor but not host MHC class II Journal of Clinical Investigation. ,vol. 106, pp. 1003- 1010 ,(2000) , 10.1172/JCI10467
Yong T. Shin, David H. Adams, Lauri R. Wyner, Enver Akalin, Mohamed H. Sayegh, Morris J. Karnovsky, Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model. Transplantation. ,vol. 59, pp. 1647- 1653 ,(1995) , 10.1097/00007890-199506270-00001
H. Auchincloss, R. Lee, S. Shea, J. S. Markowitz, M. J. Grusby, L. H. Glimcher, The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 3373- 3377 ,(1993) , 10.1073/PNAS.90.8.3373
Robert I Lechler, Giovanna Lombardi, J Richard Batchelor, Nancy Reinsmoen, Fritz H Bach, The molecular basis of alloreactivity Immunology Today. ,vol. 11, pp. 83- 88 ,(1990) , 10.1016/0167-5699(90)90033-6
HELENA ISONIEMI, MARKKU NURMINEN, MATTI J. TIKKANEN, EEVA VON WILLEBRAND, LEENA KROGERUS, JUHANI AHONEN, BJÖRN EKLUND, KRISTER HÖCKERSTEDT, KAIJA SALMELA, PEKKA HÄYRY, Risk factors predicting chronic rejection of renal allografts. Transplantation. ,vol. 57, pp. 68- 72 ,(1994) , 10.1097/00007890-199401000-00013
DONALD V. CRAMER, FRANCES A. CHAPMAN, GUO-DO WU, JO B. HARNAHA, SHIQUANG QIAN, LEONARD MAKOWKA, Cardiac transplantation in the rat. II. Alteration of the severity of donor graft arteriosclerosis by modulation of the host immune response. Transplantation. ,vol. 50, pp. 554- 558 ,(1990) , 10.1097/00007890-199010000-00004