Preclinical Properties of N4-Hexadecyl- and N4- Octadecyl-1-β-D-Arabinofuranosylcytosine in Liposomal Preparations
作者： R. A. Schwendener , D. H. Horber , C. Ottiger , H. Schott
DOI: 10.3109/08982109509039906
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摘要: AbstractThe long chain N4-alkyl compounds N4-hexadecyl- and N4-octadecyl-1-β-D-arabinofuranosylcytosine (NHAC, NOAC) are new lipophilic derivatives of 1-β-D-arabinofuranosylcytosine (ara-C). They have the strongest antitumor activities in L1210 leukemia model among series substituents ranging from C6 to C22. Long circulating liposome formulations NHAC NOAC containing poly(ethylene)glycol modified lipids (PEG-liposomes) a better activity compared with plain liposomes. However, examination interactions both liposomal blood components revealed that drug is transferred liposomes at fast rates, regardless composition. mainly bound albumin, high low density lipoproteins HDL LDL erythrocytes. Thus, serve as pharmaceutical formulation permit solubilisation thei...
informapharmascience.com参考文章(41)
Varsha Gandhi, W. Plunkett, Cellular pharmacodynamics of anticancer drugs. Seminars in Oncology. ,vol. 20, pp. 50- 63 ,(1993)
Tateshi Kataoka, Yoshio Sakurai, Effect and Mode of Action of N4-Behenoyl-β-D-Arabinofuranosylcytosine Recent results in cancer research. ,vol. 70, pp. 147- 151 ,(1980) , 10.1007/978-3-642-81392-4_15
D. Papahadjopoulos, E. Mayhew, Y. M. Rustum, C. Dave, Inhibition of Tumor Cell Growth in Vitro and in Vivo by 1-β-d-Arabinofuranosylcytosine Entrapped within Phospholipid Vesicles Cancer Research. ,vol. 36, pp. 4406- 4411 ,(1976)
P. A. Cassileth, R. P. Gale, Brian James Bolwell, High dose cytarabine: a review. Leukemia. ,vol. 2, pp. 253- 260 ,(1988)
Theresa M. Allen, Christian Hansen, Yeen Cheel Chin, Tarun Mehra, Stealth Liposomes: An Improved Sustained Release System for 1-β-d-Arabinofuranosylcytosine Cancer Research. ,vol. 52, pp. 2431- 2439 ,(1992)
Emil Frei, James S. Hewlett, Montague Lane, Robert W. Talley, John N. Bickers, William V. Leary, Dose Schedule and Antitumor Studies of Arabinosyl Cytosine (NSC 63878) Cancer Research. ,vol. 29, pp. 1325- 1332 ,(1969)
Shigeru Tsukagoshi, Yoshio Sakurai, Hidehiko Kobayashi, Torao Ishida, Jun-ichi Oh-ishi, Michiko Aoshima, Antitumor activities of newly synthesized N4-acyl-1-beta-D-arabinofuranosylcytosine. Cancer Research. ,vol. 36, pp. 2726- 2732 ,(1976)
Richard L. Momparler, A Model for the Chemotherapy of Acute Leukemia with 1-β-d-Arabinofuranosylcytosine Cancer Research. ,vol. 34, pp. 1775- 1787 ,(1974)
Kiyoji Kimura, Ryuzo Ohno, Ichita Amaki, Kenichi Hattori, Yutaka Hirota, Akira Hoshino, Michito Ichimaru, Munemoto Ito, Ikuo Kimura, Tadashi Maekawa, Toru Masaoka, Toru Nakamura, Makoto Ogawa, Masao Oguro, Kazuo Ohta, Shigeyuki Osamura, Masanori Shimoyama, Fumimaro Takaku, Yoshiro Uzuka, Kazumasa Yamada, Treatment of acute myelogenous leukemia in adults with N4-behenoyl-1-β-D-arabinofuranosylcytosine Cancer. ,vol. 56, pp. 1913- 1917 ,(1985) , 10.1002/1097-0142(19851015)56:8<1913::AID-CNCR2820560803>3.0.CO;2-W
R. A. Schwendener, H. Schott, Treatment of l1210 murine leukemia with liposome‐incorporated N4‐hexadecyl‐1‐β‐D‐arabinofuranosyl cytosine International Journal of Cancer. ,vol. 51, pp. 466- 469 ,(1992) , 10.1002/IJC.2910510321