Lipophilic Prodrugs and Formulations of Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer
作者： Godefridus J. Peters , Auke D. Adema , Irene V. Bijnsdorp , Marit L. Sandvold
DOI: 10.1080/15257770.2011.607143
关键词:
摘要: Many drugs that are currently used for the treatment of cancer have limitations, such as induction resistance and/or poor biological half-life, which reduce their clinical efficacy. To overcome these several strategies been explored. Chemical modification by attachment lipophilic moieties to (deoxy)nucleoside analogs should enhance plasma change biodistribution, and improve cellular uptake drug. Attachment a moiety phosphorylated analog will activity circumventing rate-limiting activation step analogs. Encapsulating in nanoparticles or liposomes protects drug against enzymatic breakdown makes it possible get compounds tumor site. In this review, we discuss considerable progress has made increasing efficacy classic fluoropyrimidine chemical modifications ...
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