Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils.

摘要: Dendritic cells (DCs) have a key role in orchestrating immune responses and are considered important targets for immunotherapy against cancer. In order to develop effective cancer vaccines, detailed knowledge of the micromilieu lesions is warranted. this study, flow cytometry human transcriptome arrays were used characterize subsets DCs head neck squamous cell tonsillar compare them their counterparts benign tonsils evaluate subset-selective biomarkers associated with We describe, first time, four cancer: CD123+ plasmacytoid (pDC), CD1c+, CD141+, CD1c-CD141- myeloid (mDC). An increased frequency an elevated mDC/pDC ratio shown malignant compared tissue. The microarray data demonstrates characteristics specific tonsil DC subsets, including expression immunosuppressive molecules lower levels genes involved development effector tissue, Finally, we present target candidates selectively expressed by different confirm CD206/MRC1 CD207/Langerin on CD1c+ at protein level. This study descibes context add valuable steps towards future DC-based therapies