An Efficient and Improved Method for the Preparation of Nitriles from Primary Amides and Aldoximes

摘要: The pivaloyl chloride-pyridine system has been utilized as a novel and efficient reagent for the preparation of nitriles from primary amides aldoximes. reaction proceeds smoothly under mild conditions products are obtained in excellent yields. This method is applicable to wide range substrates including aromatic, heterocyclic aliphatic species. dehydration takes place at room temperature case dichloromethane reflux required rapid conversion