Genetic variants in AKR1B10 associate with human eating behavior
作者： Kerstin Rohde , Martin Federbusch , Annette Horstmann , Maria Keller , Arno Villringer
DOI: 10.1186/S12863-015-0189-9
关键词:
摘要: The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to family aldoketoreductases and may be involved in detoxification nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished brain regions potentially regulation eating behavior rats which are more sensitive cocaine alcohol. We hypothesized that also play a role behavior. investigated effects 5 genetic variants on among 548 subjects from German self-contained population, Sorbs, 350 another independent cohort. Among we observed nominal associations with disinhibition at 5′ untranslated region (5′ UTR) variant rs10232478 intragenic rs1834150 rs782881 (all P ≤ 0.05). detected relationship waist, smoking consumption (rs782881) coffee (rs1834150) Albeit non-significant, replication analyses revealed similar effect directions for (combined P = 0.0096). Moreover, cohort found related increased restraint scores direction as Sorbs P = 0.0072). Our data suggest locus influence
biomedcentral.com
springer.com
mpg.de
core.ac.uk
qucosa.de
paperity.org
researchgate.net 参考文章(49)
E. J. Bryant, N. A. King, J. E. Blundell, Disinhibition: its effects on appetite and weight regulation Obesity Reviews. ,vol. 9, pp. 409- 419 ,(2007) , 10.1111/J.1467-789X.2007.00426.X
Ania M. Jastreboff, Edward C. Gaiser, Peihua Gu, Rajita Sinha, Sex differences in the association between dietary restraint, insulin resistance and obesity. Eating Behaviors. ,vol. 15, pp. 286- 290 ,(2014) , 10.1016/J.EATBEH.2014.03.008
Sungshim Lani Park, Iona Cheng, Sarah A. Pendergrass, Anna M. Kucharska-Newton, Unhee Lim, Jose Luis Ambite, Christian P. Caberto, Kristine R. Monroe, Fredrick Schumacher, Lucia A. Hindorff, Matthew T. Oetjens, Sarah Wilson, Robert J. Goodloe, Shelly-Ann Love, Brian E. Henderson, Laurence N. Kolonel, Christopher A. Haiman, Dana C. Crawford, Kari E. North, Gerardo Heiss, Marylyn D. Ritchie, Lynne R. Wilkens, Loïc Le Marchand, Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations The PAGE Study American Journal of Epidemiology. ,vol. 178, pp. 780- 790 ,(2013) , 10.1093/AJE/KWT028
Anke Tönjes, Eleftheria Zeggini, Peter Kovacs, Yvonne Böttcher, Dorit Schleinitz, Kerstin Dietrich, Andrew P Morris, Beate Enigk, Nigel W Rayner, Moritz Koriath, Markus Eszlinger, Anu Kemppinen, Inga Prokopenko, Katrin Hoffmann, Daniel Teupser, Joachim Thiery, Knut Krohn, Mark I McCarthy, Michael Stumvoll, Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. European Journal of Human Genetics. ,vol. 18, pp. 104- 110 ,(2010) , 10.1038/EJHG.2009.107
Jana Breitfeld, Anke Tönjes, Marie-Therese Gast, Dorit Schleinitz, Matthias Blüher, Michael Stumvoll, Peter Kovacs, Yvonne Böttcher, Role of Vaspin in Human Eating Behaviour PLoS ONE. ,vol. 8, pp. e54140- ,(2013) , 10.1371/JOURNAL.PONE.0054140
Toru Nishinaka, Takeshi Miura, Manami Okumura, Fumika Nakao, Haruka Nakamura, Tomoyuki Terada, None, Regulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2. Chemico-Biological Interactions. ,vol. 191, pp. 185- 191 ,(2011) , 10.1016/J.CBI.2011.01.026
Yi Shen, Linlin Zhong, Stephen Johnson, Deliang Cao, Human aldo–keto reductases 1B1 and 1B10: A comparative study on their enzyme activity toward electrophilic carbonyl compounds Chemico-Biological Interactions. ,vol. 191, pp. 192- 198 ,(2011) , 10.1016/J.CBI.2011.02.004
M-W Kang, E-S Lee, SY Yoon, J Jo, J Lee, HK Kim, YS Choi, K Kim, YM Shim, J Kim, H Kim, AKR1B10 is associated with smoking and smoking-related non-small-cell lung cancer. Journal of International Medical Research. ,vol. 39, pp. 78- 85 ,(2011) , 10.1177/147323001103900110
James W. Hull, John F. Clarkin, Gerard P. Smith, Edward N. Shearin, Mark J. Russ, Construct validity of the Three-Factor Eating Questionnaire: flexible and rigid control subscales. International Journal of Eating Disorders. ,vol. 16, pp. 187- 198 ,(1994) , 10.1002/1098-108X(199409)16:2<187::AID-EAT2260160210>3.0.CO;2-U
Anne C. Choquette, Simone Lemieux, Angelo Tremblay, Vicky Drapeau, Claude Bouchard, Marie-Claude Vohl, Louis Pérusse, GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study. Physiology & Behavior. ,vol. 98, pp. 505- 510 ,(2009) , 10.1016/J.PHYSBEH.2009.08.004