GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study.
作者： Anne C. Choquette , Simone Lemieux , Angelo Tremblay , Vicky Drapeau , Claude Bouchard
DOI: 10.1016/J.PHYSBEH.2009.08.004
关键词:
摘要: The glutamate decarboxylase 2 (GAD2) gene encodes for the glutamic acid enzyme (GAD65), which is implicated in formation of gamma-aminobutyric (GABA), a neurotransmitter involved regulation food intake. objective present study was to test association between GAD2 single-nucleotide polymorphisms (SNPs) and eating behaviors, dietary intake obesity subjects (n=873) from Quebec Family Study (QFS). Energy macronutrient intakes were measured using 3-day record behaviors assessed Three-Factor Eating Questionnaire (TFEQ). Six SNPs capturing about 90% variability genotyped tested with age- BMI- adjusted phenotypes. No evidence found men. In women, SNP (rs992990; c.61450 C>A) associated disinhibition (p=0.028), emotional susceptibility (p=0.0005) hunger (p=0.028). Another (rs7908975; c.8473A>C) carbohydrate (p=0.021) lipid intakes, (p=0.011) two its subscales (emotional situational susceptibility) as well avoidance fattening foods (p=0.036). Six-year weight gain times higher women carrying variants behaviors: 4.2kg (vs 2.1kg non-carriers) A-allele carriers C>A (p=0.038) 4.9kg 2.5kg C-allele c. 8473 A>C (p=0.013). results suggest role determining intake, over time women.
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