Reuse of Molecules for Glioblastoma Therapy.

摘要: Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with DNA alkylator temozolomide; however, survival under this treatment regimen an abysmal 12-18 months. New and emerging treatments include application physical device, non-invasive 'tumor treating fields' (TTFs), including its use care; varied vaccines immunotherapeutics being trialed. Some these approaches have extended life few months over care, but in some cases are only available minority patients. Extensive activity also underway to repurpose reposition therapeutics GBM, either alone or combination care. In review, we present select molecules that target different pathways at various stages clinical translation as case studies illustrate rationale their repurposing-repositioning potential use.