Indirubin-type compounds, compositions, and methods for their use
作者： Marie Knockaert , Alexios-Leandros Skaltounis , Laurent Meijer , Paul Greengard
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摘要: Compounds and compositions including 6-bromo-indirubin, 5-amino-indirubin N-methyl-indirubins related indirubin derivatives are provided that useful as selective modulators of glycogen synthase kinase-3, cyclin-dependent protein kinases or aryl hydrocarbon receptors. Methods inhibiting modulating cell growth cycling using the compounds invention. In other aspects, methods for treatment protozoan-mediated diseases, Alzheimer's disease diabetes provided.
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