A Double-Blind Placebo-Controlled Investigation of the Efficacy of Modafinil for Maintaining Alertness and Performance in Sustained Military Ground Operations

摘要: Abstract : With the advent of 24/7 warfighter, novel pharmaceutical agents have come to forefront interest for maintaining sustained operations. The eugregoric, modafinil, was administered during an 88-hr sleep loss study evaluate its performance maintenance capability. A modafinil dosing schedule (100/100/200 mg), would maintain cognitive and psychomotor at or near baseline levels throughout experimental period. repeated measures, double blind design used examine 100 200 mg doses every eight hours twelve participants. Cognitive physiological tests were presented iteratively sessions. results this provide some evidence that partially attenuates decrement caused by in field environments, thus increasing likelihood successful mission accomplishment. As anticipated, had very little impact upon physical performance, no adverse physiologic effects, produced few side effects. Modafinil may negatively but effect appears minimal should be investigated a controlled manner. universal acceptance our participants, observed mild advantages, low health risk, make it candidate applications.