Bronchial responsiveness to eucapnic hyperventilation and methacholine following exposure to organic dust.

摘要: Study objective Inhalation of dust in a swine confinement building causes an intense airway inflammatory reaction the airways and increased bronchial responsiveness to methacholine. The aims present study were investigate whether exposure organic also influences indirect stimulus, assess duration postexposure responsiveness. Design Twenty-two healthy nonatopic, nonsmoking subjects exposed for 3 h building. Lung function was assessed, either methacholine provocation (n = 11) or challenge with eucapnic hyperventilation dry air performed before at 7 h, 1 week, 2 weeks, 4 weeks after exposure. Results Vital capacity FEV decreased 3% 6%, respectively (p fell from 1.38 mg (25th 75th percentiles, 0.75 7.20 mg) 0.18 (0.11 0.30 0.004). Corresponding values dose-response slope 15.3%/mg (2.88 25.3%/mg) 100.2%/mg (2.1 27.3%/mg), 0.01). Bronchial not affected by exposure: 4.3% (− 7.2 − 1.8%) 4.8% 6.7 1.6%) 0.72). One week exposure, normalized. Conclusions but increases house dust. Thus, induces different characteristics that frequently found asthma.