Chelerythrine, analogs thereof and their use in the treatment of bipolar disorder and other cognitive disorders

摘要: The present invention relates to the use of chelerythrine and analogs in pharmaceutical compositions for treatment prefrontal cortical cognitive disorders, including bipolar disorder, among others. Pharmaceutical according comprise an effective amount a compound or stereoisomer, pharmaceutically acceptable salt, solvate polymorph thereof structure: formula (I) (II) wherein: R1 R2 are independently selected from H, C1-C3alkyl, F, Cl, Br, I, OH, O(C1-C6 alkyl), O-C(=O)-(C1-C6)alkyl C(=O)-O-(C1-C6)alkyl; R3 is H C1-C6alkyl group; R4, R5, R6 , R7 R8 C1-C6alkyl, -(CH2)nO(C1-C6alkyl), -(CH2)nO-C(=O)-(C1-C6)alkyl -(CH2)n R9 R10 C1-C6alkyI together form -(CH2)m-group produce 5-7-membered ring; n 0 5; m 1 3; A- anion which forms salt with quaternized amine group, optionally combination carrier, additive excipient.