In Silico Logical Modelling to Uncover Cooperative Interactions in Cancer.

摘要: The multistep development of cancer involves the cooperation between multiple molecular lesions, as well complex interactions cells and surrounding tumour microenvironment. search for these synergistic using experimental models made tremendous contributions to our understanding oncogenesis. Yet, approaches remain labour-intensive challenging. To tackle such a hurdle, an integrative, multidisciplinary effort is required. In this article, we highlight use logical computational models, combined with validations, effective approach identify cooperative mechanisms therapeutic strategies in context biology. silico overcome limitations reductionist by capturing complexity generating powerful testable hypotheses. We review representative examples reported literature their validation. then provide further analyses model Epithelium Mesenchymal Transition (EMT), searching additional involving inputs from microenvironment gain function mutations NOTCH.