Fibrinogen degradation products in serum and urine of patients with systemic lupus erythematosus. Relation to renal disease and pathogenetic mechanism.

摘要: Serum and concentrated urine from blood donors, patients with rheumatoid arthritis SLE without renal disease were tested for the presence of fibrinogen degradation products (FDP), using tanned red cell hemagglutination inhibition immunoassay. The majority donors had serum titers 1:2 to 1:4, while systemic lupus erythematosus 1:8 1:32. FDP detected in low nearly all disease, whereas elevated found active disease. Several possible sources urinary are discussed, role fibrin deposition glomerular injury is reviewed.