A Reversible pH-Driven DNA Nanoswitch Array

摘要: An array of surface-immobilized proton-fueled DNA nanomachines is reversibly actuated by cycling the solution pH between 4.5 and 9, producing a conformational change four-stranded double-stranded structure, which elongates or shortens separation distance 5‘ 3‘ end DNA. By labeling with fluorophore immobilizing it onto thin-gold surface through its thiol modification, nanoscale motion produces mechanical work to lift up bring down from gold at least 2.5 nm transduces this into an optical “on-and-off” nanoswitch.