DNA methylation and genetic instability

摘要: Methylation of DNA constitutes an epigenetic mechanism, which regulates genetic expression and gene imprinting. has the property altering stability, because it alters conformational state DNA. can not only affect normal functioning mismatch repair pathway, but also influence alter pattern in disease processes. Abnormal methylation is associated with conditions, such as fragile X, ICF, Rett syndromes. Histone acetylation deacetylation are closely neoplastic process. The activation p53 its turnover important components cell-cycle regulatory mechanism. dynamics involved both these components. role that histone acetyl transferase (HAC) deacetylases (HDAC) play controlling cellular proteins been heavily underscored by their recognition potential targets for cancer therapy attempts to develop new strategies treatment based on employment HDAC inhibitors.