Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas

作者： Clinical S Tudy

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摘要: Objective: To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). Methods: Fourteen PAs were studied by comparative genomic hybridization (CGH). Results: The fourteen showed imbalances. All cases except one exhibited two or more abnormalities. Chromosomal found all cases, three (21%) also presented losses. Genomic amplification was not observed. Chromosome 9 involved ten cases. Recurrent genetic gain on 9p22 ‐ 24 9q34, each 6 of 14 (43%). Other recurrent included Xq26 (43%) 4q21 28 8p22 23, 4 (29%). Regions loss whole chromosome 11 20q12 13, 2 (14%). Conclusions: Our findings show imbalances CGH, partly confirming previous reports, with the exception that we observed than Several regions (9p22 24, Xq26, 28, 23) probably deserve further investigation order to discard presence genes tumorigenesis.

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参考文章(32)

Ritva Karhu, Martin Bäckdahl, Anders Höög, Catharina Larsson, Magnus Kjellman, Olli-P. Kallioniemi, Lars-Ove Farnebo, Gert Auer, Genetic Aberrations in Adrenocortical Tumors Detected Using Comparative Genomic Hybridization Correlate with Tumor Size and Malignancy Cancer Research. ,vol. 56, pp. 4219- 4223 ,(1996)

Masami Kuramochi, Hiroshi Fukuhara, Takahiro Nobukuni, Takamasa Kanbe, Tomoko Maruyama, Hara P. Ghosh, Mathew Pletcher, Minoru Isomura, Masataka Onizuka, Tadaichi Kitamura, Takao Sekiya, Roger H. Reeves, Yoshinori Murakami, TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nature Genetics. ,vol. 27, pp. 427- 430 ,(2001) , 10.1038/86934

Randall D. Gaz, Hideki Tahara, Alison P. Smith, Vincent L. Cryns, Andrew Arnold, Genomic Localization of Novel Candidate Tumor Suppressor Gene Loci in Human Parathyroid Adenomas Cancer Research. ,vol. 56, pp. 599- 605 ,(1996)

A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641

Samuli Hemmer, Veli-Matti Wasenius, Caj Haglund, Ying Zhu, Sakari Knuutila, Kaarle Franssila, Heikki Joensuu, Deletion of 11q23 and Cyclin D1 Overexpression Are Frequent Aberrations in Parathyroid Adenomas The American Journal of Pathology. ,vol. 158, pp. 1355- 1362 ,(2001) , 10.1016/S0002-9440(10)64086-2

Begoña Arribas, Eva Cristóbal, José A. Alcázar, Juan Tardío, Juan C. Martínez-Montero, José R. Polo, Rafael Carrión, Laura Gil, Marta Azañedo, José M. Rojas, José M. Rojas, p53/MDM2 Pathway Aberrations in Parathyroid Tumors: p21(WAF-1) and MDM2 Are Frequently Overexpressed in Parathyroid Adenomas. Endocrine Pathology. ,vol. 11, pp. 251- 257 ,(2000) , 10.1385/EP:11:3:251

S. H. S. Pearce, D. Trump, C. Wooding, M. N. Sheppard, R. N. Clayton, R. V. Thakker, Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptibility (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours. Clinical Endocrinology. ,vol. 45, pp. 195- 200 ,(1996) , 10.1046/J.1365-2265.1996.D01-1561.X

Christina Heppner, Mary Beth Kester, Sunita K. Agarwal, Larisa V. Debelenko, Michael R. Emmert-Buck, Siradanahalli C. Guru, Pachiappan Manickam, Shodimu-Emmanuel Olufemi, Monica C. Skarulis, John L. Doppman, Richard H. Alexander, Young S. Kim, Suraj K. Saggar, Irina A. Lubensky, Zhengping Zhuang, Lance A. Liotta, Settara C. Chandrasekharappa, Francis S. Collins, Alien M. Spiegel, A. Lee Burns, Stephen J. Marx, Somatic mutation of the MEN1 gene in parathyroid tumours. Nature Genetics. ,vol. 16, pp. 375- 378 ,(1997) , 10.1038/NG0897-375

H Tahara, A P Smith, R D Gaz, A Arnold, Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas. The Journal of Clinical Endocrinology and Metabolism. ,vol. 81, pp. 3663- 3667 ,(1996) , 10.1210/JCEM.81.10.8855819

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Nallasivam Palanisamy, Yasuo Imanishi, Pulivarthi H. Rao, Hideki Tahara, R. S. K. Chaganti, Andrew Arnold, Novel Chromosomal Abnormalities Identified by Comparative Genomic Hybridization in Parathyroid Adenomas The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 1766- 1770 ,(1998) , 10.1210/JCEM.83.5.4806

Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas

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Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas

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