A pilot study on the usefulness of a new test for mass screening of colorectal cancer in Japan

摘要: A new screening test (Shamsuddin and Elsayed, 1988) based on the enzymatic detection of disaccharide Β-D-Gal(1→ 3)-D-GalNAc in rectal mucus patients with colorectal (CR) cancer precancerous conditions such as inflammatory bowel disease (IBD) polyp (precancerous lesions) was evaluated 85 Japanese patients. Following a 15-minute reaction, sensitivity 80.0% (8/10) for CR 72.2% (8/11) lesions obtained. The overall specificity combined cancers 62.2% (28/45). Correlation abnormal mucin production tissues studied by high-iron diamine-Alcian blue and/or periodic acid-Schiff-Alcian (pH= 1.0). agreement results this 77.8% (7/9) 75.0% (6/8) conditions. Because simplicity test, low cost, stability sample reagents accuracy lesions, may have potential use mass high risk individuals, particularly Japan.