Nuclear Overhauser Enhancement imaging of glioblastoma at 7 Tesla: region specific correlation with apparent diffusion coefficient and histology.

摘要: Objective To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing apparent diffusion coefficient (ADC) cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that originates mobile macromolecules such as proteins might be associated with via altered protein synthesis proliferating cells. Patients Methods For 15 patients newly diagnosed glioblastoma, NOE-mediated CEST-contrast was acquired at 7 Tesla (asymmetric magnetization ratio (MTRasym) 3.3ppm, B1 = 0.7 μT). Contrast enhanced T1 (CE-T1), T2 diffusion-weighted MRI (DWI) were 3 coregistered. The edema CE-T1 segmented. ADC MTRasym values within both regions interest correlated voxelwise yielding rSpearman (rSp). In three who underwent stereotactic biopsy, 12 specimens per patient corresponding biopsy site. Results Eight showed a weak or moderate positive (0.16≤rSp≤0.53, p 0.05, n 4) yielded rSp≈0 (p 6). biopsy-analysis revealed strong two (rSppatient3 0.69 rSppatient15 0.87, p<0.05), while heterogeneous 0.545 0.067), rSppatient4 -0.021 0.948), -0.755 0.005)). Discussion NOE-imaging new contrast promising insight into pathophysiologic processes regarding content, setting itself apart DWI. Future studies based on assumption CEST visualizes more accurately than ADC, especially region.