Melatonin effects on Schiff's base levels induced by iodide administration in rats

摘要: OBJECTIVES: Administration of iodides to animals, living in iodine-deficient areas, can induce necrosis and fibrosis the thyroid gland. It is believed that structural functional changes may be related oxidative processes. Increased lipid peroxidation levels were reported murine glands after high doses iodine. Melatonin (MEL) exert its effects via electron donation directly detoxify free radicals, such as, e.g., highly toxic hydroxyl radical. In numerous reports antioxidative action MEL, authors have considered protective ability this hormone against lipids. The goal study was evaluate processes role MEL three organs rat (the liver, brain, lungs) during treatment with different iodide. MATERIAL AND METHODS: Schiff’s bases (SB) concentrations (a parameter stress) measured lung brain homogenates male Wistar rats. animals received their diet following concentrations, for 2 weeks: Group 1 – Controls (standard normal-iodine diet, containing approx. 0.7 mg kalium iodide per kg; KI/kg); 0,25 KI/kg; 3 4,0 4 8,0 KI/kg. 5 standard alone a dose mg/kg BW i.p. at 3.00 pm, every day two weeks. Subsequent groups (6–8) KI as above, respectively, together MEL. RESULTS: We noted increased SB lungs when compared those observed controls. also found decreased liver an administration but unexpectedly level group highest iodine homogenates. suggest involved not only other tissues, protects iodine-induced stress. CONCLUSION: Our results confirm differences among examined organs. These alterations possibly sensitivity rates tissues damage.