H2O2 induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin
作者： Ewa Sewerynek , Burkhard Poeggeler , Daniela Melchiorri , Russel J. Reiter
DOI: 10.1016/0304-3940(95)11803-5
关键词:
摘要: Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) assayed as an index induced membrane oxidative damage. Brain were co-incubated with H2O2 alone or combination melatonin. MDA + 4-HDA increased after (0.1-5 mM) the effect being both concentration- and time-dependent. protected a concentration-dependent manner.
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