Liposomal bupivacaine - New trends in Anesthesia and Intensive Care Units

作者: Alexandru Florin Rogobete , Ovidiu Horea Bedreag , Mirela Sărăndan , Marius Păpurică , Gabriela Preda

DOI: 10.1016/J.EGJA.2014.12.004

关键词:

摘要: Abstract Progress made on local anesthetics controlled release formulation and their ability to induce motor sensory block for a longer period of time brings significant advantages in clinical practice. The use sustained formulations provides analgesia long with one administration, thus limiting the complications that can occur conventional analgesia. Also, biologically active compound prevents overdosing, minimizing side effects, especially cardiotoxicity, neurotoxicity tissue lesions. Clinical liposomal high impressive results pain control quick patient recovery. Increased comfort, reducing half hospital length stay, treatment costs are able provide higher level healthcare.

参考文章(62)
A P Rubin, H A McLure, Review of local anaesthetic agents. Minerva Anestesiologica. ,vol. 71, pp. 59- 74 ,(2005)
Rupen Mackwana, Veena R Shah, Kalpana Vora, Spinal Anaesthesia in Ambulatory Surgery: Dose-Response Characteristics of Constant Volume Bupivacaine Indian Journal of Anaesthesia. ,vol. 52, pp. 191- ,(2008)
Casati A, Di Cianni S, Leone S, Fanelli G, Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Bio Medica Atenei Parmensis. ,vol. 79, pp. 92- 105 ,(2008)
Gaurav Kuthiala, Geeta Chaudhary, Ropivacaine: A review of its pharmacology and clinical use. Indian Journal of Anaesthesia. ,vol. 55, pp. 104- 110 ,(2011) , 10.4103/0019-5049.79875
I. Ciuca, L. Pop, Z. Popa, L. Tamas, B. Almajan Guta, P. Matusz, 187 Evaluation of cystic fibrosis liver disease and the relation with risk factors in a Romanian centre Journal of Cystic Fibrosis. ,vol. 13, ,(2014) , 10.1016/S1569-1993(14)60322-2
Mary K. Clark, Lipid Emulsion as Rescue for Local Anesthetic-Related Cardiotoxicity Journal of PeriAnesthesia Nursing. ,vol. 23, pp. 111- 121 ,(2008) , 10.1016/J.JOPAN.2008.01.005
Jong Hoon Choi, Ji Young Jang, Yoon Ki Joung, Myung Hee Kwon, Ki Dong Park, Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A. Journal of Controlled Release. ,vol. 147, pp. 420- 427 ,(2010) , 10.1016/J.JCONREL.2010.07.118
Famin Qiu, Rami Mhanna, Li Zhang, Yun Ding, Satoshi Fujita, Bradley J. Nelson, Artificial bacterial flagella functionalized with temperature-sensitive liposomes for controlled release Sensors and Actuators B-chemical. ,vol. 196, pp. 676- 681 ,(2014) , 10.1016/J.SNB.2014.01.099
F. Maestrelli, M.L. González-Rodríguez, A.M. Rabasco, C. Ghelardini, P. Mura, New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. International Journal of Pharmaceutics. ,vol. 395, pp. 222- 231 ,(2010) , 10.1016/J.IJPHARM.2010.05.046
Bassam Al-Nasser, Long-acting local anesthetics at home: do we need to worry? Journal of Clinical Anesthesia. ,vol. 19, pp. 239- 240 ,(2007) , 10.1016/J.JCLINANE.2006.12.002