Cannabis sativa subsp. sativa's pharmacological properties and health effects: A scoping review of current evidence.

摘要: Introduction Hemp (Cannabis sativa subsp. sativa), commonly used for industrial purposes, is now being consumed by the public various health promoting effects. As popularity of hemp research and claims beneficial effects rises, a systematic collection current scientific evidence on hemp's pharmacological properties needed to guide future research, clinical, policy decision making. Objective To provide an overview identify present landscape topics, trends, gaps. Methods A search analysis strategy according preferred reporting items review meta-analysis-ScR (PRISMA-ScR) checklist electronic databases including MEDLINE, OVID (OVFT, APC Journal Club, EBM Reviews), Cochrane Library Central Clinicaltrials.gov was conducted include analyse articles from 2009 2019. Results 65 primary (18 47 pre-clinical) were reviewed. Several randomised controlled trials showed hempseed pills (in Traditional Chinese Medicine formulation MaZiRenWan) improving spontaneous bowel movement in functional constipation. There also suggesting benefits cannabis dependence, epilepsy, anxiety disorders. Pre-clinically, derivatives potential anti-oxidative, anti-hypertensive, anti-inflammatory, anti-diabetic, anti-neuroinflammatory, anti-arthritic, anti-acne, anti-microbial activities. Renal protective estrogenic exhibited vitro. Conclusion Current hemp-specific interventions are still preliminary, with limited high quality clinical any specific therapeutic indication. This mainly due wide variation test item formulation, as multiple variants this plant differ their phytochemical bioactive compounds. Future empirical should focus standardising pharmaceutical use, uniformity experimental designs strengthen premise using medicine.